Malignant Mesothelioma

Malignant mesothelioma: In the chest and abdominal cavities, as well as in the cavity around the heart (pericardial sac), there is a layer of specialized cells called mesothelial cells. These cells also surround the outer surface of most internal organs. These cells form tissue called mesothelium.

The mesothelium performs a protective function for the internal organs by producing a lubricating fluid that permits the organs to move around. For example, this fluid makes it easier for the lungs to move inside the chest while a person breathes. The mesothelium of the abdomen is known as the peritoneum, and the mesothelium of the chest is called the pleura. The pericardium refers to the mesothelium of the pericardial cavity.

There are three primary types of malignant mesotheliomas:

• Epithelioid. About 50% to 70% of mesotheliomas are of this type and have the best outlook for survival.
• Sarcomatoid. Approximately 7% to 20% of cases are of this type.
• Mixed/biphasic. From 20% to 35% of mesothelioma cases fall into this category.